https://gordondalephd.com/home daily 1.0 2021-03-13 https://static1.squarespace.com/static/602339d16c992a7aded903b0/t/6045ae4993caaf08592ec70d/1615179534845/IMG_0818.jpg Home - About Me I’m Gordon - an early career physician scientist interested in how the immune system harnesses evolution to develop humoral immunity. https://static1.squarespace.com/static/602339d16c992a7aded903b0/t/60332307ccc1ba13869db5b3/1614059300804/national-cancer-institute-L7en7Lb-Ovc-unsplash.jpg Home - The Research Understanding the pathways of DNA repair that generate diversity during the humoral immune response. https://static1.squarespace.com/static/602339d16c992a7aded903b0/t/603326965a30be43ec04dce7/1614059333073/national-cancer-institute-J28Nn-CDbII-unsplash.jpg Home - An Integrated Model How do the tandem processes of gene conversion and somatic hypermutation relate to one another and what are the implications of these dual processes? https://gordondalephd.com/about daily 0.75 2021-08-20 https://static1.squarespace.com/static/602339d16c992a7aded903b0/t/60347c26d2e98007cf35a1be/1614052410327/143755653_10115108739566728_7453154941242368213_o.jpg About https://static1.squarespace.com/static/602339d16c992a7aded903b0/t/60347eeba81ab103e5e7a0c1/1614053109448/151039603_10115207259387218_139572087303361280_n.jpg About https://static1.squarespace.com/static/602339d16c992a7aded903b0/t/60347d07e6060e2c92fef506/1614052654936/DSC_0055.JPG About https://static1.squarespace.com/static/602339d16c992a7aded903b0/t/60348127482c2804787ce29d/1614053681703/20181103_234133.jpg About https://gordondalephd.com/research daily 0.75 2021-03-12 https://static1.squarespace.com/static/602339d16c992a7aded903b0/t/603494d92054e8790f556c87/1614204111073/Germinal_center.png The Research https://gordondalephd.com/model daily 0.75 2021-02-24 https://gordondalephd.com/contact daily 0.75 2021-02-23 https://gordondalephd.com/nfts daily 0.75 2021-05-03 https://static1.squarespace.com/static/602339d16c992a7aded903b0/t/608c5aaf84ec1b386f5b826d/1620055280009/20171217_171813.jpg NFTs - Why NFTs for science? Even as a scientist, science is difficult. It is difficult to design, difficult to do, difficult still to interpret. I view NFTs as a way to bridge that gap. A way for an average person to try to connect with the science community that so often seems distant - locked away in an Ivory Tower of some far off land. Here, I’ve listed the stories surrounding my NFTs. Importantly, these NFTs do not represent published research, but rather they give the holder a glimpse into the scientific world and how human it truly is. https://gordondalephd.com/listings daily 0.75 2021-05-03 https://static1.squarespace.com/static/602339d16c992a7aded903b0/t/608f972ca15efc6c86ca779d/1620055252688/BerekAndMilstein1987.png NFT Listings - NFT # 1 Gene Conversion in Berek & Milstein (1987) https://static1.squarespace.com/static/602339d16c992a7aded903b0/t/608c5efbadc53479d5c15b6e/1620053820351/ NFT Listings - NFT #2 30 years later (Lab notes of J Jacob) https://gordondalephd.com/berekmilstein daily 0.75 2021-05-03 https://static1.squarespace.com/static/602339d16c992a7aded903b0/t/6090027f81655a7d061cfe39/1620022700206/BerekAndMilstein1987.png Berek&Milstein - The NFT I chose to mint this slide because it represents a unique moment in the history of antibody research. At the former home of Benedictine monks in Venice, this slide was shown to a future Nobel Laureate and other researchers whose contribution to science was a foundation for vaccine efforts, including with COVID-19. What is notable about this slide is that it shows data from a study from a Nobel Laureate’s lab 30 years prior and supports a radical change in thinking about antibody diversity. Ultimately, it also showcases how we as scientists have difficulty accepting new perspectives on matters previously considered settled. It is one that is somewhat warranted and somewhat antithetical to the idea of science, in which we are supposed to constantly evaluate our held beliefs against new data. While I am personally not sure what the correct amount of skepticism is, I wanted to mint this slide to immortalize that concept and the duality of dogma and innovation in science. https://static1.squarespace.com/static/602339d16c992a7aded903b0/t/608f92793740bc15209f91af/1620021931321/Picture3.png Berek&Milstein https://static1.squarespace.com/static/602339d16c992a7aded903b0/t/608f823df520a47177e0fa8e/1620022893754/Picture2.png Berek&Milstein - The Venue These immunological giants gathered at San Servolo Island in Venice, Italy from September 14-17th, 2017. It was by and far the most interesting venue for a scientific conference that I had ever attended before and since then. Former Benedictine monastery and later psychiatric hospital, the island lies near the mouth of the Giudecca canal and is only accessible via boat that would arrive once an hour. To those unfortunate enough to miss the last ferry for the day, they would be marooned on the island for the night. The conference began promptly each day at 8am. During my time in Venice, I stayed on the main island and would take the ferry each morning to arrive for the opening sessions. https://static1.squarespace.com/static/602339d16c992a7aded903b0/t/608f96c8ea005e63fcce0d2f/1620022995749/20210503_022052.jpg Berek&Milstein - The Presentation On the morning of September 16th, I arrived early via ferry. As the ferry glided through the Venetian lagoon, my nerves were wracked - Today was the day my PI would present my work. The day prior I had presented a poster of the work and was met with stern resistance. Thoughts flashed in my head about what my PI would face. Arriving a couple of minutes before the session began, I walked my PI through the major points of the presentation I had made days prior. He seemed nervous but assured me that this was how he always was before a presentation. We then went over the most pivotal slide of the presentation. This was a slide that showed historical evidence of gene conversion. A slide of work of a Nobel laureate’s lab. A slide about one of the most fundamental aspects of the antibody response. https://static1.squarespace.com/static/602339d16c992a7aded903b0/t/6090115897f23228cfcafb47/1620054453217/GCC2017-participants.jpg Berek&Milstein Participants from the 19th GCC. Image credit: IFOM